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Periodontitis and incidence of cerebrovascular disease in men

Identifieur interne : 005687 ( Main/Exploration ); précédent : 005686; suivant : 005688

Periodontitis and incidence of cerebrovascular disease in men

Auteurs : Monik Jimenez [États-Unis] ; Elizabeth A. Krall ; Raul I. Garcia ; Pantel S. Vokonas ; Thomas Dietrich [Royaume-Uni]

Source :

Annals of neurology [ 0364-5134 ] ; 2009.

RBID : PMC:2783821

Abstract

Objective

To identify associations between periodontitis and incidence of cerebrovascular disease.

Methods

We analyzed data of 1,137 dentate men in the VA Normative Aging and Dental Longitudinal Study who were followed with triennial medical/dental exams for up to 34 years (mean 24 years). We evaluated incidence of cerebrovascular events consistent with stroke or transient ischemic attack in relation to mean radiographic alveolar bone loss (a measure of periodontitis history) and cumulative periodontal probing depth (a measure of current periodontal inflammation). Cox proportional hazards models were fit controlling for age, baseline socio-economic status and time varying effects of established cardiovascular risk factors.

Results

Eighty incident cases of cerebrovascular disease occurred from 27,506 person-years. Periodontal bone loss was significantly associated with an increased hazard rate of cerebrovascular disease (HR: 3.52, 95% CI: 1.59, 7.81 comparing highest to lowest bone loss category, p for trend <0.001). There was a stronger effect among men aged <65 yrs (HR: 5.81, 95% CI: 1.63, 20.7) as compared to men ≥65 yrs (HR: 2.39, 95% CI: 0.91, 6.25). Periodontal probing depth was not associated with a significantly increased rate of cerebrovascular disease in the combined or age stratified analyses.

Interpretation

These results support an association between history of periodontitis - but not current periodontal inflammation - and incidence of cerebrovascular disease in men, independent of established cardiovascular risk factors, particularly among men younger than 65 years.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783821

DOI: 10.1002/ana.21742
PubMed: 19847898
PubMed Central: 2783821

Affiliations:

Le document en format XML

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</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">We analyzed data of 1,137 dentate men in the VA Normative Aging and Dental Longitudinal Study who were followed with triennial medical/dental exams for up to 34 years (mean 24 years). We evaluated incidence of cerebrovascular events consistent with stroke or transient ischemic attack in relation to mean radiographic alveolar bone loss (a measure of periodontitis history) and cumulative periodontal probing depth (a measure of current periodontal inflammation). Cox proportional hazards models were fit controlling for age, baseline socio-economic status and time varying effects of established cardiovascular risk factors.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Eighty incident cases of cerebrovascular disease occurred from 27,506 person-years. Periodontal bone loss was significantly associated with an increased hazard rate of cerebrovascular disease (HR: 3.52, 95% CI: 1.59, 7.81 comparing highest to lowest bone loss category, p for trend <0.001). There was a stronger effect among men aged <65 yrs (HR: 5.81, 95% CI: 1.63, 20.7) as compared to men ≥65 yrs (HR: 2.39, 95% CI: 0.91, 6.25). Periodontal probing depth was not associated with a significantly increased rate of cerebrovascular disease in the combined or age stratified analyses.</p>
</sec>
<sec id="S4"><title>Interpretation</title>
<p id="P4">These results support an association between history of periodontitis - but not current periodontal inflammation - and incidence of cerebrovascular disease in men, independent of established cardiovascular risk factors, particularly among men younger than 65 years.</p>
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Periodontitis and incidence of cerebrovascular disease in men

Periodontitis and incidence of cerebrovascular disease in men

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Abstract

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